Senior Director Manufacturing (Biologics), Brussels

A biologics manufacturing organization is seeking a Senior Director of Manufacturing to lead large-scale mammalian cell culture operations (mAbs) across clinical and commercial programs.

This is a highly visible leadership role responsible for end‑to‑end cGMP manufacturing, regulatory readiness, and operational performance at a rapidly expanding site. The role requires a hands‑on, execution-focused leader who can operate at both the strategic and operational level, partnering closely with senior leadership and cross‑functional teams.

Key Responsibilities

Lead and oversee cGMP manufacturing operations for biologic drug substance (mAbs) across clinical and commercial stages

Manage and develop a large‑scale manufacturing organization (~200+ FTEs)

Drive site performance, scalability, and operational excellence during a period of expansion

Partner closely with Quality and senior leadership to ensure inspection readiness and compliance

Play a key role in regulatory inspections (FDA and others), including direct involvement during audits

Support manufacturing contributions to IND/BLA filings (preferred)

Act as a primary point of contact for clients during site visits and manufacturing discussions

Implement and drive continuous improvement and LEAN manufacturing systems

Lead organizational growth, including team scaling, structure, and talent development

Required Qualifications

Extensive experience in biologic drug substance manufacturing (protein experience strongly preferred)

Background in mammalian cell culture manufacturing

Proven leadership of large, complex manufacturing teams (100+)

Strong experience in clinical and commercial manufacturing environments

Demonstrated involvement in regulatory inspections and compliance readiness

Experience in CDMO or similarly fast‑paced manufacturing environments strongly preferred

Track record of driving operational improvements, scalability, and performance outcomes

Additional Information

Onsite role, 5 days/week

Standard travel expectations, including client‑facing responsibilities

Role is part of an expanded leadership structure at a growing manufacturing site

Target Candidate Profile

Experience in biologics manufacturing at scale (CDMO experience highly preferred)

Background leading organizations through growth, scale‑up, and regulatory milestones

Demonstrated success in building high‑performing teams in complex environments

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